SCHEMBL28257537

SCHEMBL28257537

CC(C)(C)c1cc2c(c(O)c1C(C)(C)C)Cc1ccccc1-2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.40
RAB9A P51151 3/20 0.40
ALDH1A1 P00352 3/20 0.40
KDM4E B2RXH2 2/20 0.40
MAPT P10636 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
PNMT P11086 1/20 0.37
CA2 P00918 1/20 0.35
TSHR P16473 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
PTPN1 P18031 1/20 0.34
EGFR P00533 1/20 0.34
ERBB2 P04626 1/20 0.34
IGF1R P08069 1/20 0.34
SLC6A2 P23975 2/20 0.33
SLC6A4 P31645 2/20 0.33
HTR2C P28335 2/20 0.33
HTR2B P41595 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28204552 0.75 CA2 (0.50) NPC1RAB9AALDH1A1KDM4EMAPT
SCHEMBL27530433 0.75 CA2 (0.46) NPC1RAB9AALDH1A1KDM4EMAPT
SCHEMBL32687413 0.74 PNMT (0.41) NPC1RAB9AALDH1A1KDM4EMAPT
SCHEMBL20241461 0.74 PNMT (0.41) NPC1RAB9AALDH1A1KDM4EMAPT
SCHEMBL28320033 0.73 SQOR (0.37) NPC1RAB9AALDH1A1KDM4EMAPT
SCHEMBL27705952 0.72 HSP90AA1 (0.43) NPC1RAB9AALDH1A1KDM4EMAPT
SCHEMBL2043313 0.72 PNMT (0.49) NPC1RAB9AALDH1A1KDM4EMAPT
Hydrochloric Acid SCHEMBL15558045 0.72
SCHEMBL28214865 0.71 NPC1 (0.43) NPC1RAB9AALDH1A1KDM4EMAPT
SCHEMBL9528210 0.71 CA1 (0.46) CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108779305-A Low crystalline polymer composition prepared in dual reactor 埃克森美孚化学专利公司 2018-11-09 CN disclosed