Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | ATP4A | P20648 | 1/20 | 0.36 |
| ▸ | ATP4B | P51164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30735529 | 0.78 | GAA (0.47) | MAPTNPSR1GAANPC1HTR1A | |
| SCHEMBL27801325 | 0.76 | MAPT (0.48) | MAPTNPSR1GAANPC1POLB | |
| SCHEMBL31506852 | 0.76 | MAPT (0.48) | MAPTNPSR1GAANPC1POLB | |
| SCHEMBL24373066 | 0.75 | CD44 (0.39) | MAPTGAANPC1POLBALDH1A1 | |
| SCHEMBL31503772 | 0.74 | MAPT (0.47) | MAPTNPSR1GAANPC1HTR1A | |
| SCHEMBL18935874 | 0.74 | MAPT (0.68) | MAPTNPSR1GAANPC1HTR2C | |
| SCHEMBL26091619 | 0.73 | NPC1 (0.42) | MAPTNPSR1GAANPC1HTR1A | |
| SCHEMBL26607051 | 0.73 | NPSR1 (0.36) | MAPTNPSR1GAANPC1HTR1A | |
| Hydrochloric Acid SCHEMBL6475701 | 0.73 | ATP4A (0.44) | MAPTNPSR1GAANPC1HTR1A | |
| SCHEMBL21195972 | 0.72 | CA1 (0.36) | MAPTGAAALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790733-B2 | 8-alkoxy or cycloalkoxy-4-methyl-3,4-dihydro-quinazolin-2-ylamines | HOFFMAN-LA ROCHE INC. (US) | 2010-09-07 | — | — | US | disclosed |
| EP-1899307-B1 | 8-ALK0XY-4-METHYL-3, 4-DIHYDR0-QUINAZ0LIN-2-YL AMINES AND THEIR USE AS 5-HT5A RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2010-06-30 | — | — | EP | disclosed |
| EP-1899307-A1 | 8-ALK0XY-4-METHYL-3, 4-DIHYDR0-QUINAZ0LIN-2-YL AMINES AND THEIR USE AS 5-HT5A RECEPTOR LIGANDS | F. Hoffmann-Roche AG (CH) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007000393-A1 | 8-ALK0XY-4-METHYL-3 , 4-DIHYDR0-QUINAZ0LIN-2-YL AMINES AND THEIR USE AS 5-HT5A RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-04 | — | — | WO | disclosed |
| US-20060293350-A1 | 8-Alkoxy or cycloalkoxy-4-methyl-3,4-dihydro-quinazolin-2-ylamines | F. HOFFMANN-LA ROCHE AG A SWISS COMPANY (CH) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293350-A1 | 8-Alkoxy or cycloalkoxy-4-methyl-3,4-dihydro-quinazolin-2-ylamines | HTR5A, HTR2C, HTR3A | MAPT 958/4885NPSR1 48/4885GAA 514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.