Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28260986 | 1.00 | BTK (0.45) | BTKALDH1A1HSD17B10PIK3CDPIK3CA | |
| SCHEMBL533786 | 0.67 | DRD2 (0.37) | — | |
| SCHEMBL556469 | 0.66 | ESR1 (0.37) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL10966005 | 0.65 | ALDH1A1 (0.44) | ALDH1A1GRM5KMT2AMEN1 | |
| SCHEMBL11898578 | 0.64 | GPR119 (0.38) | ALDH1A1PIK3CAGRM5 | |
| SCHEMBL7659597 | 0.61 | ELANE (0.51) | ALDH1A1PIK3CAKMT2A | |
| SCHEMBL17888262 | 0.61 | NAMPT (0.53) | GRM5NAMPTKMT2A | |
| SCHEMBL15723383 | 0.59 | JAK3 (0.43) | ALDH1A1PIK3CDNAMPTKMT2AMEN1 | |
| SCHEMBL25811311 | 0.59 | JAK3 (0.43) | ALDH1A1PIK3CDNAMPTKMT2AMEN1 | |
| SCHEMBL25811372 | 0.59 | JAK3 (0.43) | ALDH1A1PIK3CDNAMPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071563-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2018-12-21 | — | — | CN | disclosed |