Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | CD38 | P28907 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826410 | 0.85 | GRM5 (0.46) | GRM5SYKPORCN | |
| SCHEMBL2826583 | 0.85 | GRM5 (0.48) | GRM5SYKS1PR1PORCNLMNA | |
| SCHEMBL2829130 | 0.82 | GRM5 (0.51) | GRM5PORCNMAPT | |
| SCHEMBL2826714 | 0.81 | GRM5 (0.70) | GRM5ABL1PDGFRBBCRSRC | |
| SCHEMBL2826236 | 0.81 | GRM5 (0.49) | GRM5SYK | |
| SCHEMBL2826783 | 0.81 | GRM5 (0.49) | GRM5SYKPORCNLMNAMAPK1 | |
| SCHEMBL2832991 | 0.80 | GRM5 (0.46) | GRM5SYKPORCNLMNAMAPT | |
| SCHEMBL2826248 | 0.80 | SMARCA2 (0.56) | GRM5PORCN | |
| SCHEMBL2829701 | 0.80 | GRM5 (0.48) | GRM5PORCNMAPT | |
| SCHEMBL2830980 | 0.80 | GRM5 (0.48) | GRM5SYKGAALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |