Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | IDE | P14735 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826583 | 0.86 | GRM5 (0.48) | GRM5SYKPORCNSMARCA2SMARCA4 | |
| SCHEMBL2826404 | 0.85 | GRM5 (0.47) | GRM5SYKPORCN | |
| SCHEMBL2829130 | 0.83 | GRM5 (0.51) | GRM5PORCNSMARCA2SMARCA4MEN1 | |
| SCHEMBL2826236 | 0.81 | GRM5 (0.49) | GRM5SYK | |
| SCHEMBL2826783 | 0.81 | GRM5 (0.49) | GRM5SYKPORCNSMARCA2SMARCA4 | |
| SCHEMBL2832991 | 0.81 | GRM5 (0.46) | GRM5SYKPORCNSMARCA2SMARCA4 | |
| SCHEMBL2826248 | 0.80 | SMARCA2 (0.56) | GRM5PORCNMAPK9MAPK10SMARCA2 | |
| SCHEMBL2830980 | 0.80 | GRM5 (0.48) | GRM5SYKMEN1KMT2A | |
| SCHEMBL2829701 | 0.80 | GRM5 (0.48) | GRM5PORCNMEN1KMT2A | |
| SCHEMBL2826714 | 0.80 | GRM5 (0.70) | GRM5PORCNSMARCA2SMARCA4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |