Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.40 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829130 | 0.83 | GRM5 (0.51) | GRM5PORCNMAPTNPC1RAB9A | |
| SCHEMBL2826783 | 0.81 | GRM5 (0.49) | GRM5GPR142PORCNSYKMAPT | |
| SCHEMBL2826236 | 0.81 | GRM5 (0.49) | GRM5SYKFYN | |
| SCHEMBL2826583 | 0.81 | GRM5 (0.48) | GRM5PORCNSYKMAPTSMN1; SMN2 | |
| SCHEMBL2826410 | 0.81 | GRM5 (0.46) | GRM5PORCNSYKMEN1KMT2A | |
| SCHEMBL2826248 | 0.80 | SMARCA2 (0.56) | GRM5PORCNNPC1RAB9AJAK2 | |
| SCHEMBL2829701 | 0.80 | GRM5 (0.48) | GRM5PORCNMAPTNPC1ALDH1A1 | |
| SCHEMBL2830980 | 0.80 | GRM5 (0.48) | GRM5SYKMAPTSMN1; SMN2KDM4E | |
| SCHEMBL2826404 | 0.80 | GRM5 (0.47) | GRM5PORCNSYKMAPTLMNA | |
| SCHEMBL2830138 | 0.80 | GRM5 (0.49) | GRM5PORCNJAK2SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |