Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | GPX4 | P36969 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.35 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28329234 | 0.74 | — | — | |
| SCHEMBL31088779 | 0.69 | NOTUM (0.40) | MAP4K4PIM1GPX4GSK3BPIM3 | |
| SCHEMBL20936728 | 0.69 | AR (0.42) | ARALDH1A1KDM4ENOTUM | |
| SCHEMBL28265674 | 0.68 | WDR5 (0.36) | PIM1PIM3AR | |
| SCHEMBL11748390 | 0.66 | FADS1 (0.54) | GSK3BKDM4E | |
| SCHEMBL28309019 | 0.66 | — | — | |
| SCHEMBL31382040 | 0.66 | AR (0.37) | MAP4K4PIM1GPX4GSK3BPIM3 | |
| SCHEMBL20906999 | 0.66 | NOTUM (0.40) | MAP4K4PIM1GPX4GSK3BPIM3 | |
| SCHEMBL20606593 | 0.66 | HCAR2 (0.38) | MAP4K4PIM1GPX4GSK3BPIM3 | |
| SCHEMBL28265669 | 0.64 | SYK (0.38) | MAP4K4PIM1GPX4GSK3BPIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109195965-A | The inhibitor that WDR5 protein-protein combines | 普罗佩纶治疗公司 | 2019-01-11 | — | — | CN | claimed |