Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.56 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2427655 | 0.81 | JAK2 (0.50) | HDAC1HDAC6RAB9ANPC1HDAC3 | |
| SCHEMBL11780084 | 0.78 | LMNA (0.58) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL14958536 | 0.78 | LMNA (0.62) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL28269947 | 0.78 | LMNA (0.50) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL28459162 | 0.77 | MCL1 (0.57) | HDAC1HDAC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11591966 | 0.76 | LMNA (0.69) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL1571386 | 0.76 | LMNA (1.00) | LMNAHIF1AROCK2ROCK1PIM1 | |
| SCHEMBL1134989 | 0.75 | HDAC1 (0.69) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL19539240 | 0.75 | HDAC1 (0.69) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL4535243 | 0.75 | LMNA (0.58) | LMNAHIF1AROCK2ROCK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109942575-A | Pyrrolopyridine as kinase inhibitor | 阵列生物制药公司 | 2019-06-28 | — | — | CN | disclosed |
| CN-104926810-B | Pyrrolopyridine as kinase inhibitor | 阵列生物制药公司 | 2019-02-19 | — | — | CN | disclosed |