Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.57 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.56 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.56 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.56 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.56 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14082511 | 0.85 | DEGS1 (0.62) | LMNASMN1; SMN2TDP1KMT2A | |
| SCHEMBL696662 | 0.82 | KMT2A (0.58) | HDAC6KMT2AHTT | |
| SCHEMBL3419853 | 0.81 | GAA (0.55) | LMNAPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL6642201 | 0.76 | KMT2A (0.67) | LMNAHIF1AROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL17627060 | 0.75 | CCNA2 (0.72) | LMNAHIF1APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL28268366 | 0.75 | LMNA (0.61) | LMNAHIF1APIM1PIM3PIM2 | |
| SCHEMBL6646471 | 0.75 | RAB9A (0.70) | LMNAHIF1AROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL31414959 | 0.75 | RAB9A (0.70) | LMNAHIF1AROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL7163550 | 0.75 | MEN1 (0.66) | LMNASMN1; SMN2HDAC1HDAC6KCNK3 | |
| SCHEMBL3421073 | 0.75 | NPC1 (0.63) | SMN1; SMN2KCNK3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3126347-B1 | SUBSTITUTED PYRAZOLYL-NICOTIN(THIO)AMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2018-10-17 | — | — | EP | disclosed |
| US-10039283-B2 | Substituted pyrazolyl-nicotin(thio)amide derivatives and their use as fungicides | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-08-07 | — | — | US | disclosed |
| US-20170142969-A1 | SUBSTITUTED PYRAZOLYL-NICOTIN(THIO)AMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-05-25 | — | — | US | disclosed |
| EP-3126347-A1 | SUBSTITUTED PYRAZOLYL-NICOTIN(THIO)AMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | Bayer CropScience Aktiengesellschaft (DE) | 2017-02-08 | — | — | EP | disclosed |
| WO-2015150352-A1 | SUBSTITUTED PYRAZOLYL-NICOTIN(THIO)AMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2015-10-08 | — | — | WO | disclosed |
| US-20090105264-A1 | Substituted Nicotinamide Compounds | MERCK SHARP & DOHME CORP. | 2009-04-23 | — | — | US | disclosed |
| EP-1945028-A2 | SUBSTITUTED NICOTINAMIDE COMPOUNDS | Merck & Co., Inc. (US) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007055942-A2 | SUBSTITUTED NICOTINAMIDE COMPOUNDS | MERCK & CO., INC. (US) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170142969-A1 | SUBSTITUTED PYRAZOLYL-NICOTIN(THIO)AMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | NAPRT, PIR, NAT1 | LMNA 3206/4885HIF1A 4664/4885PIM1 837/4885 |
| US-10039283-B2 | Substituted pyrazolyl-nicotin(thio)amide derivatives and their use as fungicides | NAPRT, PIR, NAT1 | LMNA 3206/4885HIF1A 4664/4885PIM1 837/4885 |
| US-20090105264-A1 | Substituted Nicotinamide Compounds | SIRT1, NQO1, TXNRD2 | LMNA 2553/4885HIF1A 1397/4885PIM1 3421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.