Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 3/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830880 | 0.85 | GRM5 (0.47) | GRM5HTTKMT2ARAB9ALMNA | |
| SCHEMBL2826392 | 0.83 | GRM5 (0.48) | GRM5HTTKMT2ARAB9ANPC1 | |
| SCHEMBL2826008 | 0.83 | GRM5 (0.57) | GRM5LCKHTTKMT2ASMN1; SMN2 | |
| SCHEMBL2826781 | 0.83 | GRM5 (0.52) | GRM5KMT2ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2827009 | 0.82 | GRM5 (0.53) | GRM5HTTKMT2ARAB9ANPC1 | |
| SCHEMBL2827196 | 0.80 | GRM5 (0.58) | GRM5LCKKMT2ANPC1LMNA | |
| SCHEMBL2824785 | 0.80 | GRM5 (0.70) | GRM5KMT2ARAB9ANPC1JAK2 | |
| SCHEMBL2830236 | 0.79 | GRM5 (0.71) | GRM5SGMS2JAK2JAK3KDM4E | |
| SCHEMBL2826273 | 0.78 | GRM5 (0.56) | GRM5LCKHTTRAB9ANPC1 | |
| SCHEMBL2830049 | 0.78 | GRM5 (0.60) | GRM5HTTSMN1; SMN2LMNAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |