Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827009 | 0.87 | GRM5 (0.53) | GRM5BRAFNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2829701 | 0.86 | GRM5 (0.48) | GRM5BRAFNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2826781 | 0.85 | GRM5 (0.52) | GRM5BRAFNPC1SMN1; SMN2ABL1 | |
| SCHEMBL2825999 | 0.84 | LMNA (0.41) | GRM5BRAFNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2826714 | 0.83 | GRM5 (0.70) | GRM5ABL1PDGFRBBCRPDGFRA | |
| SCHEMBL2827196 | 0.83 | GRM5 (0.58) | GRM5NPC1ABL1CYP11B2JAK2 | |
| SCHEMBL2826867 | 0.81 | CDK4 (0.45) | GRM5BRAFNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2829312 | 0.81 | GRM5 (0.52) | GRM5NPC1RAB9ASMN1; SMN2CDK4 | |
| SCHEMBL2824785 | 0.81 | GRM5 (0.70) | GRM5NPC1RAB9AJAK2JAK3 | |
| SCHEMBL2826008 | 0.80 | GRM5 (0.57) | GRM5SMN1; SMN2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |