Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | FGR | P09769 | 1/20 | 0.44 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.44 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.44 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.44 |
| ▸ | CSK | P41240 | 1/20 | 0.44 |
| ▸ | TXK | P42681 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | BLK | P51451 | 1/20 | 0.44 |
| ▸ | BMX | P51813 | 1/20 | 0.44 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.44 |
| ▸ | EPHA5 | P54756 | 1/20 | 0.44 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831282 | 0.87 | NPC1 (0.43) | — | |
| SCHEMBL2826236 | 0.86 | GRM5 (0.49) | ROCK1LCKFYNYES1LYN | |
| SCHEMBL2826867 | 0.84 | CDK4 (0.45) | — | |
| SCHEMBL2830181 | 0.84 | ROCK1 (0.46) | ROCK1LCKSYKTYRO3 | |
| SCHEMBL2833176 | 0.84 | SORT1 (0.41) | — | |
| SCHEMBL2826585 | 0.83 | GRM5 (0.52) | — | |
| SCHEMBL2830050 | 0.83 | BRAF (0.46) | — | |
| SCHEMBL2830257 | 0.81 | GRM5 (0.50) | — | |
| SCHEMBL2829325 | 0.78 | JAK2 (0.41) | — | |
| SCHEMBL2828980 | 0.78 | SORT1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |