Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 4/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 7/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 6/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828939 | 0.89 | SMARCA2 (0.48) | SMARCA2SMARCA4PIK3CAMAPK8MAPK9 | |
| SCHEMBL2827627 | 0.87 | SMARCA2 (0.43) | SMARCA2SMARCA4PIK3CAMAPK8MAPK9 | |
| SCHEMBL2828980 | 0.86 | SORT1 (0.41) | SORT1MAPK10NPC1CASP3RAB9A | |
| SCHEMBL2826248 | 0.85 | SMARCA2 (0.56) | SORT1SMARCA2SMARCA4PIK3CAMAPK8 | |
| SCHEMBL2831282 | 0.85 | NPC1 (0.43) | MAPK8GRM5JAK2NPC1RAB9A | |
| SCHEMBL2830257 | 0.84 | GRM5 (0.50) | SORT1GRM5MAPTPIK3C3 | |
| SCHEMBL2825870 | 0.84 | NPC1 (0.39) | SMARCA2SMARCA4PIK3CAMAPK8MAPK9 | |
| SCHEMBL2827012 | 0.84 | ROCK1 (0.47) | — | |
| SCHEMBL2826585 | 0.83 | GRM5 (0.52) | PIK3CAGRM5JAK2MAPT | |
| SCHEMBL2826867 | 0.83 | CDK4 (0.45) | GRM5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |