Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 13/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828980 | 0.88 | SORT1 (0.41) | PIK3C3SORT1NPC1RAB9A | |
| SCHEMBL2831282 | 0.87 | NPC1 (0.43) | JAK2NPC1RAB9AKMT2ACYP1A2 | |
| SCHEMBL2828828 | 0.85 | GRM5 (0.46) | JAK2SORT1MEN1NPC1RAB9A | |
| SCHEMBL2828127 | 0.83 | SMARCA2 (0.42) | JAK2NPC1RAB9A | |
| SCHEMBL2830005 | 0.82 | SORT1 (0.35) | SORT1RAB9AKMT2A | |
| SCHEMBL2833176 | 0.82 | SORT1 (0.41) | JAK2PIK3C3SORT1NPC1RAB9A | |
| SCHEMBL2826030 | 0.81 | PIK3CA (0.37) | SORT1NPC1RAB9A | |
| SCHEMBL2830257 | 0.80 | GRM5 (0.50) | PIK3C3SORT1KMT2ACYP1A2 | |
| SCHEMBL2829131 | 0.80 | GRM5 (0.47) | JAK2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL2826649 | 0.80 | HTR2C (0.36) | PIK3C3SORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |