Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 10/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829325 | 0.88 | JAK2 (0.41) | SORT1NPC1RAB9APIK3C3 | |
| SCHEMBL2833176 | 0.86 | SORT1 (0.41) | SORT1NPC1RAB9ACASP3SENP8 | |
| SCHEMBL2830005 | 0.82 | SORT1 (0.35) | SORT1RAB9ASMN1; SMN2 | |
| SCHEMBL2826030 | 0.81 | PIK3CA (0.37) | SORT1NPC1RAB9AMAPK10SMN1; SMN2 | |
| SCHEMBL2830257 | 0.80 | GRM5 (0.50) | SORT1PIK3C3MAPT | |
| SCHEMBL2826649 | 0.80 | HTR2C (0.36) | SORT1PIK3C3SMN1; SMN2 | |
| SCHEMBL2826529 | 0.79 | SMN1; SMN2 (0.36) | SORT1PIK3C3SMN1; SMN2 | |
| SCHEMBL2831282 | 0.79 | NPC1 (0.43) | NPC1RAB9AMAPTGSK3ASMN1; SMN2 | |
| SCHEMBL2826585 | 0.79 | GRM5 (0.52) | MAPT | |
| SCHEMBL2832743 | 0.79 | SORT1 (0.34) | SORT1PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |