Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | SCD | O00767 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | GCK | P35557 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL28281665 | 0.80 | RAB9A (0.52) | NPC1RAB9ASCDLMNAMEN1 | |
| SCHEMBL28858268 | 0.76 | LMNA (0.56) | NPC1RAB9ASCDLMNAMEN1 | |
| SCHEMBL995829 | 0.76 | NPC1 (1.00) | NPC1RAB9ASCDLMNAMEN1 | |
| SCHEMBL27591943 | 0.75 | KMT2A (0.52) | NPC1RAB9ALMNAKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL8457979 | 0.75 | NPC1 (0.52) | NPC1RAB9ASCDLMNAMEN1 | |
| Hydrochloric Acid SCHEMBL27594584 | 0.74 | NPC1 (0.97) | NPC1RAB9ASCDLMNAMEN1 | |
| SCHEMBL6713640 | 0.73 | NPC1 (0.71) | NPC1RAB9ASCDLMNAMEN1 | |
| SCHEMBL9782507 | 0.72 | RBBP9 (0.51) | NPC1RAB9ASCDLMNAMEN1 | |
| SCHEMBL28520017 | 0.72 | KMT2A (0.69) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL26854309 | 0.72 | NPC1 (0.73) | NPC1RAB9ASCDLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109456279-A | Thiazoleamino benzamide acetic ester derivative and application thereof | 南华大学 | 2019-03-12 | — | — | CN | claimed |
| CN-109320473-A | Thiazoleamino benzamide acetogenin and application thereof | 南华大学 | 2019-02-12 | — | — | CN | claimed |
| CN-109456279-A | Thiazoleamino benzamide acetic ester derivative and application thereof | 南华大学 | 2019-03-12 | — | — | CN | disclosed |
| CN-109320473-A | Thiazoleamino benzamide acetogenin and application thereof | 南华大学 | 2019-02-12 | — | — | CN | disclosed |
| CN-109232467-A | Thiazoleamino benzoic acid derivative and application thereof | 南华大学 | 2019-01-18 | — | — | CN | disclosed |
| CN-109232467-A | Thiazoleamino benzoic acid derivative and application thereof | 南华大学 | 2019-01-18 | — | — | CN | disclosed |
| CN-109232467-A | Thiazoleamino benzoic acid derivative and application thereof | 南华大学 | 2019-01-18 | — | — | CN | disclosed |