Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzotriazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzotriazole SCHEMBL39112 | 1.00 | L3MBTL1 (0.39) | L3MBTL1SMN1; SMN2MAPTALDH1A1CHRM1 | |
| Benzotriazole SCHEMBL4948842 | 1.00 | L3MBTL1 (0.39) | L3MBTL1SMN1; SMN2MAPTALDH1A1CHRM1 | |
| Benzotriazole SCHEMBL28276295 | 1.00 | L3MBTL1 (0.39) | L3MBTL1SMN1; SMN2MAPTALDH1A1CHRM1 | |
| Benzotriazole SCHEMBL28212495 | 0.94 | NPC1 (0.38) | L3MBTL1SMN1; SMN2ALDH1A1CHRM1HPGD | |
| Benzotriazole SCHEMBL9019467 | 0.93 | TDP1 (0.39) | L3MBTL1SMN1; SMN2MAPTALDH1A1CHRM1 | |
| Benzotriazole SCHEMBL21629494 | 0.92 | CHRM1 (0.37) | SMN1; SMN2MAPTALDH1A1CHRM1HPGD | |
| Benzotriazole SCHEMBL27661352 | 0.92 | CHRM1 (0.37) | SMN1; SMN2MAPTALDH1A1CHRM1HPGD | |
| Benzotriazole SCHEMBL1507756 | 0.92 | CHRM1 (0.37) | SMN1; SMN2MAPTALDH1A1CHRM1HPGD | |
| Benzotriazole SCHEMBL2458393 | 0.92 | CYP3A4 (0.41) | L3MBTL1SMN1; SMN2MAPTALDH1A1CHRM1 | |
| Benzotriazole SCHEMBL27976494 | 0.92 | LMNA (0.41) | SMN1; SMN2MAPTALDH1A1CHRM1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105037523-B | Interferon mutant and its polyethyleneglycol derivative | 北京三元基因药业股份有限公司 | 2019-02-19 | — | — | CN | disclosed |