Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzotriazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzotriazole SCHEMBL39112 | 1.00 | L3MBTL1 (0.39) | L3MBTL1SMN1; SMN2MAPTALDH1A1CHRM1 | |
| Benzotriazole SCHEMBL28276295 | 1.00 | L3MBTL1 (0.39) | L3MBTL1SMN1; SMN2MAPTALDH1A1CHRM1 | |
| Benzotriazole SCHEMBL28276294 | 1.00 | L3MBTL1 (0.39) | L3MBTL1SMN1; SMN2MAPTALDH1A1CHRM1 | |
| Benzotriazole SCHEMBL28212495 | 0.94 | NPC1 (0.38) | L3MBTL1SMN1; SMN2ALDH1A1CHRM1HPGD | |
| Benzotriazole SCHEMBL9019467 | 0.93 | TDP1 (0.39) | L3MBTL1SMN1; SMN2MAPTALDH1A1CHRM1 | |
| Benzotriazole SCHEMBL21629494 | 0.92 | CHRM1 (0.37) | SMN1; SMN2MAPTALDH1A1CHRM1HPGD | |
| Benzotriazole SCHEMBL27661352 | 0.92 | CHRM1 (0.37) | SMN1; SMN2MAPTALDH1A1CHRM1HPGD | |
| Benzotriazole SCHEMBL1507756 | 0.92 | CHRM1 (0.37) | SMN1; SMN2MAPTALDH1A1CHRM1HPGD | |
| Benzotriazole SCHEMBL2458393 | 0.92 | CYP3A4 (0.41) | L3MBTL1SMN1; SMN2MAPTALDH1A1CHRM1 | |
| Benzotriazole SCHEMBL27976494 | 0.92 | LMNA (0.41) | SMN1; SMN2MAPTALDH1A1CHRM1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108219673-A | A kind of pectination polyamino acid composite antibacterial coating and preparation method thereof | 江苏卓尔医疗器械有限公司 | 2018-06-29 | — | — | CN | claimed |
| CN-100335503-C | Polyol-ifn-beta conjugates | APPLIED RESEARCH SYSTEMS (AN) | 2007-09-05 | — | — | CN | claimed |
| CN-113429559-B | Six-arm polyethylene glycol derivative with terminal iso-functionalization and preparation method thereof | 厦门赛诺邦格生物科技股份有限公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-112694608-B | Six-arm polyethylene glycol derivative, preparation method and modified biological related substance | 厦门赛诺邦格生物科技股份有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-115010915-B | Nitrogen-branched nine-arm polyethylene glycol derivative, preparation method and modified biologically-relevant substance thereof | 厦门赛诺邦格生物科技股份有限公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-110643032-B | Eight-arm polyethylene glycol, preparation method, functionalized derivative and modified biologically-relevant substance | 厦门赛诺邦格生物科技股份有限公司 | 2022-01-28 | — | — | CN | disclosed |
| CN-113429559-A | Six-arm polyethylene glycol derivative with end hetero-functionalized and preparation method thereof | 厦门赛诺邦格生物科技股份有限公司 | 2021-09-24 | — | — | CN | disclosed |
| CN-112694608-A | Six-arm polyethylene glycol derivative, preparation method and modified biologically-relevant substance | 厦门赛诺邦格生物科技股份有限公司 | 2021-04-23 | — | — | CN | disclosed |
| CN-110643032-A | Eight-arm polyethylene glycol, preparation method, functionalized derivative and modified biologically-relevant substance | 厦门赛诺邦格生物科技股份有限公司 | 2020-01-03 | — | — | CN | disclosed |
| CN-108219673-A | A kind of pectination polyamino acid composite antibacterial coating and preparation method thereof | 江苏卓尔医疗器械有限公司 | 2018-06-29 | — | — | CN | disclosed |
| CN-108047086-A | Composition containing alpha-non-natural amino acid and polypeptide, be related to the method for alpha-non-natural amino acid and polypeptide with and application thereof | AMBRX公司 | 2018-05-18 | — | — | CN | disclosed |
| CN-101918540-A | Use of LINGO-4 antagonists in the treatment of conditions involving demyelination | BIOGEN IDEC INC | 2010-12-15 | — | — | CN | disclosed |
| CN-101578264-A | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides | AMBRX INC (US) | 2009-11-11 | — | — | CN | disclosed |
| CN-101432318-A | Polymer and method of making same | WARWICK EFFECT POLYMERS LTD (GB) | 2009-05-13 | — | — | CN | disclosed |
| CN-101341118-A | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides | AMBRX INC (US) | 2009-01-07 | — | — | CN | disclosed |
| US-7468210-B1 | Cross-linked heparin coatings and methods | BIOSURFACE ENGINEERING TECHNOLOGIES, INC. (US) | 2008-12-23 | — | — | US | disclosed |
| CN-100335503-C | Polyol-ifn-beta conjugates | APPLIED RESEARCH SYSTEMS (AN) | 2007-09-05 | — | — | CN | disclosed |
| CN-1972707-A | Treatment of conditions involving demyelination | BIOGEN IDEC INC (US) | 2007-05-30 | — | — | CN | disclosed |
| CN-1694718-A | Modified asialo-interferons and uses thereof | GEN HOSPITAL CORP (US) | 2005-11-09 | — | — | CN | disclosed |
| CN-1187094-C | Polyol interferon beta conjugates | APPLIED RESEARCH SYSTEMS (AN) | 2005-02-02 | — | — | CN | disclosed |