Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.96 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.96 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.96 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA7 | P43166 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
| ▸ | CA6 | P23280 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopenthiazide SCHEMBL30561852 | 0.98 | LMNA (1.00) | LMNACYP2C9ADRA2BTDP1ALDH1A1 | |
| Cyclopenthiazide SCHEMBL49142 | 0.98 | LMNA (1.00) | LMNACYP2C9ADRA2BTDP1ALDH1A1 | |
| SCHEMBL29132641 | 0.97 | LMNA (0.98) | LMNACYP2C9ADRA2BTDP1ALDH1A1 | |
| SCHEMBL30561876 | 0.97 | LMNA (0.98) | LMNACYP2C9ADRA2BTDP1ALDH1A1 | |
| Cyclopenthiazide SCHEMBL13723122 | 0.90 | LMNA (0.85) | LMNACYP2C9ADRA2BTDP1ALDH1A1 | |
| Cyclopenthiazide SCHEMBL28832656 | 0.85 | LMNA (0.76) | LMNACYP2C9ADRA2BTDP1ALDH1A1 | |
| Cyclopenthiazide SCHEMBL28142871 | 0.85 | LMNA (0.76) | LMNACYP2C9ADRA2BTDP1ALDH1A1 | |
| Cyclothiazide SCHEMBL28279779 | 0.84 | LMNA (0.78) | LMNACYP2C9ADRA2BTDP1ALDH1A1 | |
| SCHEMBL17471640 | 0.82 | LMNA (0.72) | LMNACYP2C9ADRA2BTDP1ALDH1A1 | |
| SCHEMBL13685945 | 0.81 | TDP1 (0.79) | LMNACYP2C9ADRA2BTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154009-B1 | USE OF A THIAZIDE DIURETIC FOR THE MANUFACTURE OF A NON-DIURETIC ANTIHYPERTENSIVE MEDICAMENT | Euro-Celtique S.A. (LU) | 1993-07-14 | — | — | EP | disclosed |
| US-4898729-A | Treatment of hypertension, compounds and compositions for antihypertension and diuresis | EUROCELTIQUE, S.A. (LU) | 1990-02-06 | — | — | US | disclosed |
| EP-0154009-A1 | Use of a thiazide diuretic for the manufacture of a non-diuretic antihypertensive medicament | Euro-Celtique S.A. (LU) | 1985-09-11 | — | — | EP | disclosed |