Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 4/20 | 0.56 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.56 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.56 |
| ▸ | FABP3 | P05413 | 1/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.55 |
| ▸ | LPAR3 | Q9UBY5 | 5/20 | 0.54 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.53 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.50 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.50 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.50 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL28126920 | 1.00 | PRKCA (0.56) | PRKCAPRKCEPRKCQPRKCDFABP3 | |
| SCHEMBL8910338 | 0.90 | PRKCA (0.68) | PRKCAPRKCEPRKCQPRKCDENPP2 | |
| SCHEMBL8911157 | 0.90 | PRKCA (0.68) | PRKCAPRKCEPRKCQPRKCDENPP2 | |
| SCHEMBL19433866 | 0.90 | PRKCA (0.68) | PRKCAPRKCEPRKCQPRKCDENPP2 | |
| SCHEMBL8910329 | 0.90 | PRKCA (0.68) | PRKCAPRKCEPRKCQPRKCDENPP2 | |
| SCHEMBL14754796 | 0.84 | FABP3 (0.72) | PRKCAPRKCEPRKCQPRKCDFABP3 | |
| Choline SCHEMBL30426372 | 0.84 | ENPP2 (0.80) | FABP3ENPP2LPAR3LPAR1SMN1; SMN2 | |
| SCHEMBL18719362 | 0.83 | ENPP2 (0.71) | PRKCAPRKCEPRKCQPRKCDENPP2 | |
| SCHEMBL8002666 | 0.83 | PRKCA (0.73) | PRKCAPRKCEPRKCQPRKCDENPP2 | |
| SCHEMBL2126223 | 0.83 | PRKCA (0.73) | PRKCAPRKCEPRKCQPRKCDENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109414038-A | Compositions and methods for modulating digestibility in companion animals | 雀巢产品技术援助有限公司 | 2019-03-01 | — | — | CN | claimed |