Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | RAD52 | P43351 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 2/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1577814 | 0.83 | LMNA (0.67) | LMNAPARP1ELANEKDM4EKMT2A | |
| SCHEMBL7699184 | 0.81 | LMNA (0.51) | LMNAPARP1ELANEKDM4EKMT2A | |
| SCHEMBL30827899 | 0.81 | LMNA (0.51) | LMNAPARP1ELANEKDM4EKMT2A | |
| SCHEMBL11401006 | 0.81 | PARP1 (0.43) | LMNAPARP1ELANEKDM4EKMT2A | |
| SCHEMBL6215236 | 0.81 | TP53 (0.54) | LMNAPARP1ELANEKDM4EKMT2A | |
| Ammonia Solution, Strong SCHEMBL28093124 | 0.80 | LMNA (0.50) | LMNAPARP1ELANEKDM4EKMT2A | |
| SCHEMBL7424628 | 0.79 | LMNA (0.61) | LMNAPARP1KDM4EKMT2AMEN1 | |
| SCHEMBL30351049 | 0.78 | ESR1 (0.42) | LMNAPARP1KDM4EKMT2AMEN1 | |
| SCHEMBL13847637 | 0.75 | LMNA (0.49) | LMNAPARP1ELANEKDM4EKMT2A | |
| SCHEMBL9849397 | 0.75 | TNKS (0.47) | LMNAPARP1ELANEKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105745214-B | Tricyclic piperidine compounds | 埃科特莱茵药品有限公司 | 2019-02-19 | — | — | CN | disclosed |