Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828825 | 0.93 | KMT2A (0.40) | SMN1; SMN2ALDH1A1NPC1GAAPKM | |
| SCHEMBL2825898 | 0.91 | ALDH1A1 (0.51) | LMNASMN1; SMN2ALDH1A1NPC1GAA | |
| SCHEMBL2828384 | 0.90 | SMN1; SMN2 (0.38) | SMN1; SMN2TRPV1ALDH1A1NPC1HTT | |
| SCHEMBL2828338 | 0.86 | SMN1; SMN2 (0.41) | LMNASMN1; SMN2ALDH1A1NPC1GAA | |
| SCHEMBL2828403 | 0.86 | KMT2A (0.48) | LMNAPKMHTTPLA2G2AMEN1 | |
| SCHEMBL2828838 | 0.85 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL2829010 | 0.85 | HPGD (0.41) | SMN1; SMN2ALDH1A1NPC1GAAPKM | |
| SCHEMBL2829418 | 0.85 | MAPT (0.40) | ALDH1A1NPC1GAAPKMPTGER4 | |
| SCHEMBL1997935 | 0.84 | SMN1; SMN2 (0.35) | SMN1; SMN2TRPV1ALDH1A1GAAKDM4E | |
| SCHEMBL2828381 | 0.83 | KMT2A (0.37) | LMNASMN1; SMN2ALDH1A1GAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |