Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 3/20 | 0.40 |
| ▸ | FPR1 | P21462 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828404 | 0.91 | LMNA (0.44) | ALDH1A1GAAPKMNPC1KMT2A | |
| SCHEMBL2828825 | 0.91 | KMT2A (0.40) | ALDH1A1GAAPKMNPC1KMT2A | |
| SCHEMBL2829010 | 0.90 | HPGD (0.41) | ALDH1A1GAAPKMNPC1KMT2A | |
| SCHEMBL2829418 | 0.89 | MAPT (0.40) | ALDH1A1GAAPKMNPC1KMT2A | |
| SCHEMBL2829411 | 0.87 | TRPV1 (0.43) | ALDH1A1GAAPKMNPC1KMT2A | |
| SCHEMBL2825256 | 0.87 | ALDH1A1 (0.38) | ALDH1A1GAAPKMNPC1KMT2A | |
| SCHEMBL2829015 | 0.85 | ALDH1A1 (0.46) | ALDH1A1GAAPKMNPC1KMT2A | |
| SCHEMBL2828384 | 0.85 | SMN1; SMN2 (0.38) | ALDH1A1NPC1KMT2APOLBKDM4E | |
| SCHEMBL2828338 | 0.84 | SMN1; SMN2 (0.41) | ALDH1A1GAAPKMNPC1KMT2A | |
| SCHEMBL2828403 | 0.84 | KMT2A (0.48) | PKMKMT2AFPR1PLA2G2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |