Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | FPR1 | P21462 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828005 | 0.89 | PDE4B (0.41) | KMT2AMEN1PKMLMNAMAPT | |
| SCHEMBL2828381 | 0.89 | KMT2A (0.37) | KMT2AMEN1PKMLMNAHTT | |
| SCHEMBL2828825 | 0.87 | KMT2A (0.40) | KMT2AMEN1PKMMAPTL3MBTL1 | |
| SCHEMBL2828338 | 0.86 | SMN1; SMN2 (0.41) | KMT2AMEN1PKMLMNAMAPT | |
| SCHEMBL2828404 | 0.86 | LMNA (0.44) | KMT2AMEN1PKMLMNAHTT | |
| SCHEMBL2825898 | 0.84 | ALDH1A1 (0.51) | KMT2APKMFPR1LMNATP53 | |
| SCHEMBL2828384 | 0.83 | SMN1; SMN2 (0.38) | KMT2AMEN1HTTMAPTL3MBTL1 | |
| SCHEMBL2829802 | 0.82 | KMT2A (0.41) | KMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL2829010 | 0.82 | HPGD (0.41) | KMT2AMEN1PKMMAPTL3MBTL1 | |
| SCHEMBL2828838 | 0.82 | SMN1; SMN2 (0.35) | KMT2AMEN1LMNAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |