Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831104 | 0.92 | GRM5 (0.37) | ACSS2L3MBTL1NPC1RAB9ATP53 | |
| SCHEMBL5199075 | 0.86 | GRM5 (0.47) | ACSS2L3MBTL1NPC1RAB9ATP53 | |
| SCHEMBL2831219 | 0.86 | NPC1 (0.37) | NPC1RAB9AGRM5RAF1KDM4E | |
| SCHEMBL2825835 | 0.85 | SLC34A1 (0.34) | L3MBTL1NPC1RAB9ATP53GRM5 | |
| SCHEMBL2826935 | 0.84 | GRM5 (0.46) | ACSS2GRM5KDM4ETSHRMEN1 | |
| SCHEMBL2828252 | 0.78 | CSNK2A1 (0.35) | NPC1RAB9ARAF1 | |
| SCHEMBL2830071 | 0.78 | GRM5 (0.39) | NPC1RAB9AGRM5RAF1KDM4E | |
| SCHEMBL2827654 | 0.77 | GRM5 (0.38) | NPC1RAB9AGRM5RXFP1ALDH1A1 | |
| SCHEMBL2828486 | 0.75 | GRM5 (0.33) | RAB9AGRM5HDAC1 | |
| SCHEMBL5204048 | 0.75 | PDE10A (0.47) | ACSS2NPC1RAB9ATP53GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |