Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | HCK | P08631 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828458 | 0.85 | ACSS2 (0.36) | L3MBTL1GRM5HDAC1NPC1TP53 | |
| SCHEMBL5199983 | 0.85 | GRM5 (0.46) | L3MBTL1GRM5HDAC1NPC1TP53 | |
| SCHEMBL2831219 | 0.84 | NPC1 (0.37) | GRM5NPC1RAB9A | |
| SCHEMBL2831104 | 0.77 | GRM5 (0.37) | L3MBTL1GRM5NPC1TP53RAB9A | |
| SCHEMBL2828252 | 0.76 | CSNK2A1 (0.35) | NPC1RAB9A | |
| SCHEMBL2827654 | 0.76 | GRM5 (0.38) | GRM5NPC1RAB9A | |
| SCHEMBL2830071 | 0.75 | GRM5 (0.39) | GRM5NPC1RAB9A | |
| SCHEMBL2831317 | 0.73 | ALDH1A1 (0.34) | GRM5MEN1KMT2A | |
| SCHEMBL2824937 | 0.72 | KDM4E (0.39) | GRM5NPC1RAB9APDE4BLRRK2 | |
| SCHEMBL2828486 | 0.72 | GRM5 (0.33) | GRM5HDAC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |