Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.52 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.52 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.52 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384355 | 0.90 | KDM4E (0.70) | ACHEKDM4ETDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4383690 | 0.89 | KDM4E (0.68) | ACHECYP2D6CYP2C19NPSR1KDM4E | |
| Hydrochloric Acid SCHEMBL4377279 | 0.89 | KDM4E (0.68) | ACHEKDM4ETDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2829771 | 0.87 | ACHE (0.73) | ACHECYP2D6CYP2C19NPSR1KDM4E | |
| SCHEMBL335348 | 0.87 | RAB9A (0.66) | TDP1ALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL2836569 | 0.85 | ACHE (0.72) | ACHECYP2D6CYP2C19NPSR1KDM4E | |
| SCHEMBL182672 | 0.82 | ACHE (0.68) | ACHECYP2D6CYP2C19NPSR1KDM4E | |
| SCHEMBL2828800 | 0.81 | ACHE (0.67) | ACHECYP2D6CYP2C19NPSR1KDM4E | |
| SCHEMBL2831262 | 0.79 | NPC1 (0.76) | ACHECYP2D6CYP2C19NPSR1KDM4E | |
| SCHEMBL15134834 | 0.79 | POLB (0.68) | ACHETDP1ALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |