Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.38 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.38 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.37 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826783 | 0.89 | GRM5 (0.49) | GRM5SYKMAPK1PORCNGPR142 | |
| SCHEMBL2829461 | 0.88 | GRM5 (0.48) | GRM5ROCK1MAPK1PORCNGPR142 | |
| SCHEMBL2830226 | 0.86 | MET (0.39) | SYKBRD4ROCK1ROCK2USP2 | |
| SCHEMBL2829130 | 0.83 | GRM5 (0.51) | GRM5PORCNSMARCA2SMARCA4 | |
| SCHEMBL2826236 | 0.82 | GRM5 (0.49) | GRM5SYKROCK1 | |
| SCHEMBL2826248 | 0.81 | SMARCA2 (0.56) | GRM5PORCNSMARCA2SMARCA4 | |
| SCHEMBL2829701 | 0.81 | GRM5 (0.48) | GRM5PORCN | |
| SCHEMBL2828966 | 0.81 | GRM5 (0.40) | GRM5ROCK1MAPK1SMARCA2SMARCA4 | |
| SCHEMBL2830980 | 0.81 | GRM5 (0.48) | GRM5SYKUSP2 | |
| SCHEMBL2826714 | 0.81 | GRM5 (0.70) | GRM5PORCNSMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |