SCHEMBL28290789

SCHEMBL28290789

COC(=O)CCn1cc([N+](=O)[O-])nc1C

nearest known ligand 0.75

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.57
PKM P14618 2/20 0.52
KMT2A Q03164 2/20 0.51
MITF O75030 1/20 0.50
SOS1 Q07889 1/20 0.48
POLB P06746 3/20 0.45
MAPT P10636 1/20 0.42
HTT P42858 1/20 0.42
CASP3 P42574 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
LMNA P02545 1/20 0.38
TXNRD1 Q16881 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28290761 0.88 MITF (0.62) ALDH1A1PKMKMT2AMITFSOS1
SCHEMBL28290787 0.85 ALDH1A1 (0.54) ALDH1A1PKMKMT2AMITFSOS1
SCHEMBL4058834 0.84 ALDH1A1 (0.62) ALDH1A1PKMKMT2AMITFSOS1
SCHEMBL28290784 0.82 ALDH1A1 (0.53) ALDH1A1PKMKMT2AMITFSOS1
SCHEMBL28334488 0.79 ALDH1A1 (0.68) ALDH1A1PKMKMT2AMITFSOS1
SCHEMBL3504600 0.79 ALDH1A1 (0.68) ALDH1A1PKMKMT2AMITFSOS1
SCHEMBL18518478 0.79 CASP3 (0.45) ALDH1A1KMT2AMAPTHTTCASP3
SCHEMBL29170726 0.78 ALDH1A1 (0.66) ALDH1A1PKMKMT2AMITFSOS1
SCHEMBL13431485 0.77 ALDH1A1 (0.75) ALDH1A1PKMKMT2AMITFSOS1
SCHEMBL16324474 0.76 ALDH1A1 (0.68) ALDH1A1PKMKMT2AMITFSOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113372281-A Synthetic method of metronidazole 河北中科金辉药业有限公司 2021-09-10 CN disclosed
CN-109706198-A A kind of method that online enzyme process closes nitro imidazole derivatives 浙江工业大学 2019-05-03 CN disclosed