Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827571 | 0.88 | LMNA (0.47) | HPGDALOX15RAB9ALMNAHTT | |
| SCHEMBL2828853 | 0.88 | KMT2A (0.43) | RAB9AMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2828820 | 0.87 | KMT2A (0.42) | HPGDRAB9AMAPK1MEN1KMT2A | |
| SCHEMBL2831279 | 0.87 | RAB9A (0.41) | HPGDRAB9ALMNAHTTMEN1 | |
| SCHEMBL2829161 | 0.84 | HPGD (0.50) | HPGDALOX15RAB9ALMNAHTT | |
| SCHEMBL2830058 | 0.83 | LMNA (0.50) | HPGDALOX15RAB9ALMNAHTT | |
| SCHEMBL2830232 | 0.83 | MEN1 (0.47) | HPGDRAB9ALMNAHTTMEN1 | |
| SCHEMBL2828787 | 0.82 | MAPT (0.47) | HPGDALOX15RAB9ALMNAHTT | |
| SCHEMBL2829084 | 0.82 | HPGD (0.48) | HPGDALOX15RAB9ALMNAHTT | |
| SCHEMBL2826533 | 0.82 | ALDH1A1 (0.39) | HPGDRAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |