Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | BRAF | P15056 | 11/20 | 0.48 |
| ▸ | RAF1 | P04049 | 7/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | ROS1 | P08922 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28431898 | 0.90 | KDR (0.64) | KDRBRAFRAF1EPHX2MEN1 | |
| SCHEMBL4548050 | 0.82 | KDR (0.57) | KDRBRAFRAF1EPHX2CSF1R | |
| SCHEMBL29262259 | 0.82 | MEN1 (0.48) | KDRRAF1MEN1KMT2A | |
| SCHEMBL28292634 | 0.82 | MEN1 (0.52) | BRAFRAF1MEN1KMT2ALCK | |
| SCHEMBL28292621 | 0.81 | BRAF (0.46) | BRAFRAF1MEN1KMT2A | |
| SCHEMBL28294334 | 0.80 | LOXL2 (0.46) | KDRRAF1MEN1KMT2A | |
| SCHEMBL29186416 | 0.80 | KDR (0.45) | KDRBRAFRAF1EPHX2 | |
| SCHEMBL28963812 | 0.79 | SCN9A (0.40) | KDRBRAFRAF1MEN1KMT2A | |
| SCHEMBL28940983 | 0.79 | SCN9A (0.40) | KDRBRAFRAF1MEN1KMT2A | |
| SCHEMBL28292627 | 0.79 | SCN9A (0.41) | KDRBRAFRAF1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | claimed |
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-109689647-A | The compound that bicyclic heteroaryl replaces | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |