Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ACR | P10323 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28292627 | 0.87 | SCN9A (0.41) | BRAFRAF1KMT2AMEN1LOXL2 | |
| SCHEMBL28294334 | 0.82 | LOXL2 (0.46) | RAF1KMT2AMEN1LOXL2 | |
| SCHEMBL28940983 | 0.81 | SCN9A (0.40) | BRAFRAF1KMT2AMEN1LOXL2 | |
| SCHEMBL28963812 | 0.81 | SCN9A (0.40) | BRAFRAF1KMT2AMEN1LOXL2 | |
| SCHEMBL28292592 | 0.81 | KDR (0.53) | BRAFRAF1KMT2AMEN1 | |
| SCHEMBL20292453 | 0.80 | BRAF (0.53) | BRAFRAF1P2RX3MMP13 | |
| SCHEMBL28292566 | 0.78 | MAOB (0.49) | MAPTMMP13 | |
| SCHEMBL28292634 | 0.78 | MEN1 (0.52) | BRAFRAF1KMT2AMEN1ALDH1A1 | |
| SCHEMBL8945361 | 0.78 | ITGB3 (0.44) | S1PR1KMT2AMEN1LOXL2SMN1; SMN2 | |
| SCHEMBL6014835 | 0.77 | MMP13 (0.64) | BRAFRAF1KMT2AMEN1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | claimed |
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-109689647-A | The compound that bicyclic heteroaryl replaces | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |