Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27342036 | 1.00 | ALDH1A1 (0.42) | ALDH1A1MEN1USP2CDK4ALOX15 | |
| SCHEMBL28647947 | 1.00 | ALDH1A1 (0.42) | ALDH1A1MEN1USP2CDK4ALOX15 | |
| SCHEMBL27782379 | 0.91 | NOTUM (0.44) | ALDH1A1MEN1KMT2ANOTUMMAPT | |
| SCHEMBL28255835 | 0.79 | MAPT (0.45) | ALDH1A1MEN1USP2CDK4ALOX15 | |
| SCHEMBL27675115 | 0.79 | NOTUM (0.45) | ALDH1A1MEN1USP2CDK4ALOX15 | |
| SCHEMBL28308856 | 0.78 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL28008452 | 0.77 | MTNR1A (0.40) | MAPTLMNA | |
| SCHEMBL1102007 | 0.76 | ALDH1A1 (0.48) | ALDH1A1MEN1USP2CDK4ALOX15 | |
| SCHEMBL27483964 | 0.76 | ALDH1A1 (0.44) | ALDH1A1KMT2AGAAMAPTPOLB | |
| SCHEMBL6262183 | 0.73 | SLC6A2 (0.52) | ALDH1A1MEN1USP2CDK4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113481181-B | Recombinant esterase mutant, gene, engineering bacterium and application of recombinant esterase mutant in splitting (R, S) -indoline-2-ethyl formate | 浙江工业大学 | 2023-02-03 | — | — | CN | disclosed |
| CN-113481181-A | Recombinant esterase mutant, gene, engineering bacterium and application of recombinant esterase mutant in splitting (R, S) -indoline-2-ethyl formate | 浙江工业大学 | 2021-10-08 | — | — | CN | disclosed |
| CN-110592045-B | Recombinant esterase, gene, engineering bacterium and application of recombinant esterase to resolution of (R, S) -indoline-2-ethyl formate | 浙江工业大学 | 2021-04-06 | — | — | CN | disclosed |
| CN-109762768-B | Bacillus B8W22 and application thereof | 浙江工业大学 | 2020-08-21 | — | — | CN | disclosed |
| CN-110592045-A | Recombinant esterase, gene, engineering bacterium and application of recombinant esterase to resolution of (R, S) -indoline-2-ethyl formate | 浙江工业大学 | 2019-12-20 | — | — | CN | disclosed |
| CN-109762768-A | Bacillus B8W22 and its application | 浙江工业大学 | 2019-05-17 | — | — | CN | disclosed |
| CN-104736519-A | Indolines | HOFFMANN LA ROCHE | 2015-06-24 | — | — | CN | disclosed |
| CN-1238779-A | Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis | ELAN PHARM INC (US) | 1999-12-15 | — | — | CN | disclosed |