Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27809025 | 0.86 | ALKBH5 (0.41) | LMNAPDK2MAPTSMN1; SMN2HTT | |
| SCHEMBL27945026 | 0.86 | IP6K1 (0.39) | LMNAALDH1A1NR1H2NR1H3PDK2 | |
| SCHEMBL27648798 | 0.85 | SLC6A9 (0.42) | LMNAALDH1A1TSHRPDK2RORC | |
| SCHEMBL28258173 | 0.85 | SMN1; SMN2 (0.40) | LMNAALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL27945497 | 0.83 | IP6K1 (0.39) | LMNAALDH1A1PDK2MAPTSMN1; SMN2 | |
| SCHEMBL27859336 | 0.82 | DRD2 (0.48) | LMNAALDH1A1MAPTSMN1; SMN2DRD2 | |
| SCHEMBL28808789 | 0.81 | HDAC3 (0.32) | LMNAALDH1A1NR1H2NR1H3MAPT | |
| SCHEMBL2386743 | 0.81 | MAPT (0.55) | LMNAALDH1A1TSHRPDK2MAPT | |
| SCHEMBL29373833 | 0.81 | MAPT (0.55) | LMNAALDH1A1TSHRPDK2MAPT | |
| SCHEMBL27824902 | 0.80 | ADAMTS5 (0.42) | LMNAALDH1A1NR1H2NR1H3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641871-A | AMINOPYRIDINE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS | 诺华股份有限公司 | 2019-04-16 | — | — | CN | disclosed |