Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GRM5 | P41594 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826649 | 0.83 | HTR2C (0.36) | SORT1SMN1; SMN2ALDH1A1GRM5GLA | |
| SCHEMBL2828980 | 0.82 | SORT1 (0.41) | SORT1RAB9ASMN1; SMN2 | |
| SCHEMBL2829325 | 0.82 | JAK2 (0.41) | SORT1RAB9AKMT2A | |
| SCHEMBL2832743 | 0.82 | SORT1 (0.34) | SORT1ALDH1A1GRM5KMT2AHPGD | |
| SCHEMBL2826030 | 0.82 | PIK3CA (0.37) | SORT1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2830257 | 0.81 | GRM5 (0.50) | SORT1GRM5KMT2ANTRK1 | |
| SCHEMBL2833176 | 0.80 | SORT1 (0.41) | SORT1RAB9AGRM5 | |
| SCHEMBL2826585 | 0.80 | GRM5 (0.52) | GRM5KMT2A | |
| SCHEMBL2829067 | 0.79 | CTSK (0.35) | SORT1RAB9AALDH1A1GRM5KMT2A | |
| SCHEMBL2831282 | 0.78 | NPC1 (0.43) | RAB9APOLBSMN1; SMN2GRM5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |