SCHEMBL28293323

SCHEMBL28293323

Nc1c(-c2ccccc2)ccc2ccc(-c3ccc(F)cc3)c(N)c12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 3/20 0.49
MKNK1 Q9BUB5 1/20 0.46
MKNK2 Q9HBH9 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C9 P11712 1/20 0.46
HPGD P15428 1/20 0.46
CYP2C19 P33261 1/20 0.46
PTK2B Q14289 1/20 0.46
ADORA2A P29274 3/20 0.44
MAPT P10636 2/20 0.44
KDM4E B2RXH2 1/20 0.44
MEN1 O00255 1/20 0.40
CASP3 P42574 1/20 0.40
BLM P54132 1/20 0.40
KMT2A Q03164 1/20 0.40
NCOA1 Q15788 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28293324 0.88 ALDH1A1 (0.46) ADORA1MKNK1MKNK2HPGDADORA2A
SCHEMBL29974706 0.76 ADORA1 (0.44) ADORA1MKNK1MKNK2CYP1A2CYP2C9
SCHEMBL23579132 0.76 ADORA1 (0.44) ADORA1MKNK1MKNK2CYP1A2CYP2C9
SCHEMBL15945813 0.74 GRM2 (0.41) ADORA1MKNK1MKNK2CYP1A2CYP2C9
SCHEMBL27649740 0.73 PTGS2 (0.57) ADORA1HPGDPTGS1PTGS2TOP1
SCHEMBL20657073 0.73 HSD17B10 (0.57) CYP1A2HPGDMAPTKDM4EMEN1
SCHEMBL4107003 0.72 ALDH1A1 (0.57) HPGDMAPTKDM4EMEN1KMT2A
SCHEMBL18241028 0.71 PTGS2 (0.55) ADORA1HPGDPTGS1PTGS2TOP1
Hydrogen Sulfide SCHEMBL27719947 0.71 PTGS2 (0.55) ADORA1HPGDPTGS1PTGS2TOP1
SCHEMBL28496939 0.70 TDO2 (0.42) ADORA1HPGDMAPTKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109776590-A A kind of organic photoelectrical material and its application 中节能万润股份有限公司 2019-05-21 CN disclosed