Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29891273 | 0.88 | WDR5 (0.54) | SMN1; SMN2LMNAMAPTMAPK1MEN1 | |
| SCHEMBL28291873 | 0.81 | KDM4E (0.53) | MAPTMAPK1ALDH1A1GAA | |
| SCHEMBL29994344 | 0.80 | ALDH1A1 (0.60) | SMN1; SMN2LMNAMAPTMAPK1GFER | |
| SCHEMBL17287401 | 0.80 | ALDH1A1 (0.60) | SMN1; SMN2LMNAMAPTMAPK1GFER | |
| SCHEMBL4290148 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2LMNAMAPTMAPK1GFER | |
| SCHEMBL28845809 | 0.80 | SIRT6 (0.51) | LMNAMAPTMAPK1GFERALDH1A1 | |
| Hydrochloric Acid SCHEMBL4284845 | 0.79 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAMAPTMAPK1GFER | |
| SCHEMBL29891093 | 0.76 | WDR5 (0.59) | SMN1; SMN2LMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL29891470 | 0.75 | MAPT (0.59) | SMN1; SMN2LMNAMAPTMAPK1MEN1 | |
| SCHEMBL28845823 | 0.73 | SIRT6 (0.69) | LMNAMAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109734674-A | Phenyl amines WDR5 protein-protein interaction inhibitor and its preparation method and purposes | 中国药科大学 | 2019-05-10 | — | — | CN | disclosed |