Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 4/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827578 | 0.84 | GRM5 (0.50) | GRM5RAB9AMAPK1KDM4ENPC1 | |
| SCHEMBL2829460 | 0.83 | GRM5 (0.53) | GRM5KMT2AHTTALDH1A1 | |
| SCHEMBL2825830 | 0.81 | RAB9A (0.44) | GRM5ROCK2ROCK1SCDGCK | |
| SCHEMBL2830868 | 0.78 | MAPT (0.46) | RAB9AKDM4ENPC1GAAKMT2A | |
| SCHEMBL2828434 | 0.78 | MAPT (0.50) | ROCK2ROCK1RAB9AMAPK1KDM4E | |
| SCHEMBL2828836 | 0.77 | NPC1 (0.42) | RAB9AMAPK1KDM4ENPC1GAA | |
| SCHEMBL2830798 | 0.76 | GRM5 (0.44) | GRM5RAB9AKDM4ENPC1GAA | |
| SCHEMBL2831340 | 0.76 | NPC1 (0.47) | GRM5SCDRAB9ANPC1KMT2A | |
| SCHEMBL2828477 | 0.75 | NPC1 (0.44) | GCKRAB9AMAPK1KDM4ENPC1 | |
| SCHEMBL2829127 | 0.75 | GRM5 (0.46) | GRM5RAB9AMAPK1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |