Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.54 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.54 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602377 | 0.85 | RAB9A (0.78) | HRH4ALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL28296511 | 0.84 | RAB9A (0.73) | HRH4ALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL3644986 | 0.78 | ALDH1A1 (0.55) | HRH4ALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL3644984 | 0.78 | ALDH1A1 (0.55) | HRH4ALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL7159351 | 0.77 | RAB9A (0.56) | HRH4ALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL8276989 | 0.77 | HRH4 (0.61) | HRH4ALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL7199038 | 0.76 | ALDH1A1 (0.51) | HRH4ALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL7163069 | 0.75 | GRIN2D (0.62) | ALDH1A1SMN1; SMN2HPGDRAB9ANPC1 | |
| SCHEMBL8278363 | 0.75 | HRH4 (0.57) | HRH4ALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL8275526 | 0.74 | HRH4 (0.56) | HRH4ALDH1A1LMNASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110172051-A | IRE-1 alpha inhibitor | 复星弘创(苏州)医药科技有限公司 | 2019-08-27 | — | — | CN | disclosed |
| CN-107082770-B | IRE-1 alpha inhibitor | 复星弘创(苏州)医药科技有限公司 | 2019-04-23 | — | — | CN | disclosed |