Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14149518 | 0.82 | SIGMAR1 (0.63) | SIGMAR1TMEM97OPRM1BCHEACHE | |
| SCHEMBL28295290 | 0.81 | TMEM97 (0.50) | SIGMAR1TMEM97ACHEPYCR1MEN1 | |
| SCHEMBL28295287 | 0.80 | TMEM97 (0.48) | SIGMAR1TMEM97MMP2MMP3 | |
| SCHEMBL28293514 | 0.79 | CYP2D6 (0.51) | SIGMAR1ACHEMMP2MMP3MEN1 | |
| SCHEMBL13783914 | 0.78 | CYP1A2 (0.61) | SIGMAR1TMEM97OPRM1BCHEACHE | |
| SCHEMBL11932561 | 0.78 | SIGMAR1 (0.58) | SIGMAR1TMEM97OPRM1BCHEPYCR1 | |
| SCHEMBL6465969 | 0.76 | PYCR1 (0.61) | SIGMAR1BCHEACHEPYCR1 | |
| Anthracene SCHEMBL28783963 | 0.73 | GRIK1 (0.50) | MMP2PPARGPTGESALOX5PPARA | |
| SCHEMBL13783919 | 0.73 | HDAC1 (0.69) | SIGMAR1TMEM97OPRM1ACHE | |
| SCHEMBL8088645 | 0.72 | SIGMAR1 (0.61) | SIGMAR1TMEM97OPRM1BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110123820-A | Arginase inhibitor and its application method | 阿斯利康公司 | 2019-08-16 | — | — | CN | disclosed |
| CN-104857005-B | Arginase inhibitor and its application method | 阿斯利康公司 | 2019-04-26 | — | — | CN | disclosed |