Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 4/20 | 0.47 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28295287 | 0.85 | TMEM97 (0.48) | TMEM97SIGMAR1ALDH1A1 | |
| SCHEMBL14149935 | 0.82 | PYCR1 (0.58) | TMEM97SIGMAR1RIPK1ACHEPYCR1 | |
| SCHEMBL28295494 | 0.81 | SIGMAR1 (0.48) | TMEM97SIGMAR1ACHEPYCR1KMT2A | |
| SCHEMBL11932507 | 0.78 | TSHR (0.54) | TMEM97SIGMAR1RIPK1ACHEPYCR1 | |
| SCHEMBL15308498 | 0.76 | PYCR1 (0.61) | TMEM97SIGMAR1RIPK1ACHEPYCR1 | |
| SCHEMBL28293514 | 0.74 | CYP2D6 (0.51) | SIGMAR1ACHEKMT2AMEN1TSHR | |
| SCHEMBL28258446 | 0.73 | EPHX2 (0.45) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL28256957 | 0.72 | THRA (0.53) | SIGMAR1 | |
| SCHEMBL21895816 | 0.70 | PTGFR (0.43) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL21896387 | 0.70 | KDM4E (0.49) | KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110123820-A | Arginase inhibitor and its application method | 阿斯利康公司 | 2019-08-16 | — | — | CN | disclosed |
| CN-104857005-B | Arginase inhibitor and its application method | 阿斯利康公司 | 2019-04-26 | — | — | CN | disclosed |