Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 11/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4415348 | 0.79 | GABRA2 (0.40) | RORCCYP2C9CYP3A4CYP2C19TLR7 | |
| SCHEMBL2830711 | 0.74 | HPGD (0.44) | RORCCYP2C9CYP3A4CYP2C19GABRA2 | |
| SCHEMBL980293 | 0.74 | RORC (0.37) | RORCCYP2C9CYP3A4CYP2C19GABRA2 | |
| SCHEMBL2828899 | 0.69 | HPGD (0.43) | RORCCYP2C9CYP2C19GABRA2GABRB2 | |
| SCHEMBL2834112 | 0.68 | GABRA2 (0.43) | CYP2C9CYP2C19GABRA2GABRB2ALDH1A1 | |
| SCHEMBL980587 | 0.67 | GABRA2 (0.40) | RORCGABRA2GABRB2L3MBTL1ALDH1A1 | |
| SCHEMBL2831134 | 0.67 | HPGD (0.41) | CYP2C9CYP2C19GABRA2GABRB2ALDH1A1 | |
| SCHEMBL2828429 | 0.65 | GABRA2 (0.45) | RORCCYP2C9CYP2C19GABRA2GABRB2 | |
| SCHEMBL2829188 | 0.63 | MAPT (0.42) | RORCCYP2C9CYP3A4CYP2C19GABRA2 | |
| SCHEMBL4411178 | 0.62 | GABRA2 (0.44) | RORCCYP2C9CYP2C19GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945611-B1 | N- (HETERO) ARYL INDOLE DERIVATIVES AS PESTICIDES | NOVARTIS AG (CH) | 2010-01-06 | — | — | EP | disclosed |
| US-20090227538-A1 | N-(Hetero)Aryl Indole Derivatives as Pesticides | NOVARTIS AG (CH) | 2009-09-10 | — | — | US | disclosed |
| EP-1783114-A1 | N-(hetero)aryl indole derivatives as pesticides | Novartis AG (CH) | 2007-05-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227538-A1 | N-(Hetero)Aryl Indole Derivatives as Pesticides | IDO1, IDO2, CHRM1 | RORC 1420/4885CYP2C9 23/4885CYP3A4 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.