SCHEMBL28295855

SCHEMBL28295855

CCCc1ccccc1-c1ccccc1.CS(=O)(=O)O

nearest known ligand 0.49

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 4/20 0.42
SLC6A4 known ✓ P31645 2/20 0.42
SLC6A3 known ✓ Q01959 2/20 0.42
PPARA Q07869 2/20 0.49
KMT2A Q03164 1/20 0.46
PTGS2 P35354 1/20 0.44
DPP4 P27487 1/20 0.44
FOLH1 Q04609 1/20 0.44
PTGER1 P34995 1/20 0.44
PTGER4 P35408 1/20 0.44
PTGER3 P43115 1/20 0.44
PTGER2 P43116 1/20 0.44
PDCD1 Q15116 1/20 0.43
CD274 Q9NZQ7 1/20 0.43
CYP2D6 P10635 2/20 0.42
FFAR1 O14842 1/20 0.41
FFAR4 Q5NUL3 1/20 0.41
HDAC3 O15379 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC2 Q92769 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28293956 0.89 PPARA (0.52) PPARASOAT1
SCHEMBL5659211 0.88 KMT2A (0.47) KMT2APTGS2DPP4FOLH1PTGER1
Bicarbonate SCHEMBL1835067 0.87 PPARA (0.56) PPARAKMT2ADPP4FOLH1PTGER1
SCHEMBL607543 0.87 DPP4 (0.56) PPARAKMT2ADPP4FOLH1PTGER1
SCHEMBL27806648 0.85 PPARA (0.50) PPARAKMT2ADPP4FOLH1PTGER1
Hydrochloric Acid SCHEMBL30641921 0.85 DPP4 (0.54) PPARAKMT2ADPP4FOLH1PTGER1
Phosphoric Acid SCHEMBL14829855 0.84 PPARA (0.50) PPARAKMT2ADPP4FOLH1PTGER1
Boric Acid SCHEMBL29391822 0.84 PPARA (0.49) PPARAKMT2ADPP4FOLH1PTGER1
SCHEMBL10798302 0.83 DPP4 (0.52) PPARAKMT2ADPP4FOLH1PTGER1
SCHEMBL14842017 0.83 PPARA (0.47) PPARAPTGS2PTGER1PTGER4PTGER3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109661399-A Cross-coupling methods 芝诺罗耶尔蒂里程碑有限责任公司 2019-04-19 CN disclosed