Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | GALR2 | O43603 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15698538 | 0.81 | CCNE1 (0.61) | ACHEMAPK8CDC7HSP90AA1HSP90AB1 | |
| SCHEMBL25630336 | 0.81 | MAPK8 (0.52) | ACHEMAPK8CDC7HSP90AA1HSP90AB1 | |
| SCHEMBL25630335 | 0.79 | ROCK2 (0.68) | ACHEMAPK8CDC7HSP90AA1HSP90AB1 | |
| SCHEMBL18921584 | 0.76 | ACHE (0.54) | ACHEMAPK8CDC7HSP90AA1HSP90AB1 | |
| SCHEMBL18921585 | 0.75 | SYK (0.56) | MAPK8CDC7HSP90AA1HSP90AB1ROCK2 | |
| SCHEMBL10274926 | 0.74 | ACHE (0.57) | ACHEMAPK8CDC7CDK2 | |
| SCHEMBL4039837 | 0.73 | ACHE (0.56) | ACHEMAPK8CDC7CDK2 | |
| SCHEMBL32679532 | 0.72 | CCNE1 (0.49) | ACHEHSP90AA1HSP90AB1ROCK2ROCK1 | |
| SCHEMBL18921594 | 0.72 | HSP90AA1 (0.44) | ACHEMAPK8CDC7HSP90AA1HSP90AB1 | |
| SCHEMBL29763703 | 0.72 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109761909-A | N- (4- (pyrimidine -4- amino) phenyl) sulfonamide inhibitors or its pharmaceutical salt, preparation method and the usage | 中国药科大学 | 2019-05-17 | — | — | CN | claimed |
| CN-109761909-A | N- (4- (pyrimidine -4- amino) phenyl) sulfonamide inhibitors or its pharmaceutical salt, preparation method and the usage | 中国药科大学 | 2019-05-17 | — | — | CN | disclosed |