Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28297774 | 0.88 | KDM4E (0.50) | TRPV3GPR119PDE4BKDM4EMAPT | |
| SCHEMBL28297784 | 0.88 | KDM4E (0.50) | TRPV3GPR119PDE4BKDM4EMAPT | |
| SCHEMBL19405061 | 0.88 | GPR119 (0.52) | TRPV3GPR119PDE4BKDM4EMAPT | |
| SCHEMBL12883599 | 0.84 | GPR119 (0.49) | TRPV3GPR119KDM4EMAPTTHRB | |
| SCHEMBL12883601 | 0.84 | GPR119 (0.49) | TRPV3GPR119KDM4EMAPTTHRB | |
| SCHEMBL25042974 | 0.83 | GPR119 (0.48) | TRPV3GPR119PDE4BKDM4EMAPT | |
| SCHEMBL25044017 | 0.82 | PDE4B (0.54) | TRPV3GPR119PDE4BMAPTHPGDS | |
| SCHEMBL20438981 | 0.81 | GPR119 (0.51) | TRPV3GPR119KDM4EMAPTTHRB | |
| SCHEMBL20439007 | 0.80 | THRB (0.55) | TRPV3GPR119KDM4EMAPTTHRB | |
| SCHEMBL28812695 | 0.80 | GPR119 (0.54) | GPR119KDM4EMAPTTHRBNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715633-A | Dopamine-B-hydroxylase inhibitors | 巴尔-波特拉及康邦亚股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-109715155-A | blood brain barrier-penetrating agent dopamine- β -hydroxylase inhibitors | 巴尔-波特拉及康邦亚股份有限公司 | 2019-05-03 | — | — | CN | disclosed |