Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28297774 | 1.00 | KDM4E (0.50) | KDM4EMAPTTHRBPDE4BDPP4 | |
| SCHEMBL20439007 | 0.92 | THRB (0.55) | KDM4EMAPTTHRBDPP4TRPV3 | |
| SCHEMBL28297852 | 0.88 | TRPV3 (0.52) | KDM4EMAPTTHRBPDE4BTRPV3 | |
| SCHEMBL19405061 | 0.84 | GPR119 (0.52) | KDM4EMAPTTHRBPDE4BTRPV3 | |
| SCHEMBL22038838 | 0.83 | DPP4 (0.48) | KDM4EMAPTTHRBPDE4BDPP4 | |
| SCHEMBL20439010 | 0.81 | KDM4E (0.55) | KDM4EMAPTTHRBPDE4BDPP4 | |
| SCHEMBL28272884 | 0.81 | SMN1; SMN2 (0.47) | KDM4EMAPTTHRBPDE4BDPP4 | |
| SCHEMBL28297779 | 0.80 | PDE4B (0.56) | KDM4EMAPTTHRBPDE4BDPP4 | |
| SCHEMBL28298497 | 0.80 | PDE4B (0.56) | KDM4EMAPTTHRBPDE4BDPP4 | |
| SCHEMBL25042974 | 0.79 | GPR119 (0.48) | KDM4EMAPTTHRBPDE4BDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715633-A | Dopamine-B-hydroxylase inhibitors | 巴尔-波特拉及康邦亚股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-109715155-A | blood brain barrier-penetrating agent dopamine- β -hydroxylase inhibitors | 巴尔-波特拉及康邦亚股份有限公司 | 2019-05-03 | — | — | CN | disclosed |