SCHEMBL28297938

SCHEMBL28297938

O=C(CNc1ccccc1)Cc1ccc(Cl)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.49
MEN1 O00255 4/20 0.49
ALDH1A1 P00352 4/20 0.49
HPGD P15428 2/20 0.49
POLB P06746 2/20 0.49
MAPT P10636 2/20 0.49
L3MBTL1 Q9Y468 2/20 0.49
KLK7 P49862 4/20 0.48
LMNA P02545 1/20 0.48
GAA P10253 1/20 0.48
EGFR P00533 1/20 0.48
ERBB2 P04626 1/20 0.48
TDP1 Q9NUW8 1/20 0.47
ADAMTS5 Q9UNA0 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
NLRP3 Q96P20 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28608583 0.88 EPHX2 (0.55) KMT2AMEN1ALDH1A1MAPTL3MBTL1
SCHEMBL27979532 0.84 KMT2A (0.49) KMT2AMEN1ALDH1A1HPGDPOLB
SCHEMBL8406795 0.80 L3MBTL1 (0.66) KMT2AMEN1ALDH1A1HPGDPOLB
SCHEMBL4659306 0.77 KMT2A (0.50) KMT2AMEN1ALDH1A1HPGDMAPT
SCHEMBL9370024 0.76 KMT2A (0.77) KMT2AMEN1ALDH1A1HPGDPOLB
SCHEMBL1479915 0.75 NPC1 (0.55) KMT2AMEN1ALDH1A1HPGDPOLB
SCHEMBL8000529 0.75 ERCC1 (0.67) KMT2AMEN1ALDH1A1HPGDMAPT
SCHEMBL4327956 0.74 CTBP2 (0.52) KMT2AMEN1ALDH1A1POLBMAPT
SCHEMBL6904425 0.74 ALDH1A1 (0.46) KMT2AMEN1ALDH1A1HPGDMAPT
SCHEMBL27748604 0.74 MEN1 (0.55) KMT2AMEN1ALDH1A1HPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109912809-A Base metal-metal organic framework composite material, preparation method and application 中国科学院福建物质结构研究所 2019-06-21 CN disclosed