SCHEMBL28298959

SCHEMBL28298959

NC(=O)c1c(F)c(F)c(C(N)=O)c(F)c1F.[NaH]

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.39
CES2 O00748 1/20 0.36
CES1 P23141 1/20 0.36
HTT P42858 2/20 0.33
PARP1 P09874 1/20 0.32
LMNA P02545 2/20 0.31
ALDH1A1 P00352 1/20 0.31
OR51E2 Q9H255 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
TP53 P04637 1/20 0.31
MAPK1 P28482 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA4 P22748 1/20 0.31
GAA P10253 1/20 0.30
DGAT1 O75907 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL811680 0.97 POLB (0.41) POLBCES2CES1HTTPARP1
SCHEMBL161645 0.93 CES2 (0.42) POLBCES2CES1HTTPARP1
Bromide SCHEMBL29086958 0.90 CES2 (0.40) POLBCES2CES1HTTPARP1
SCHEMBL12544632 0.90 CES2 (0.40) POLBCES2CES1HTTPARP1
SCHEMBL1703382 0.90 CES2 (0.40) POLBCES2CES1HTTPARP1
SCHEMBL9147301 0.87 CES2 (0.42) POLBCES2CES1HTTPARP1
SCHEMBL707937 0.85 ESR1 (0.39) POLBCES2CES1HTT
SCHEMBL3145740 0.85 POLB (0.35) POLBCES2CES1HTT
SCHEMBL11044013 0.83 TAS1R3 (0.45) POLBALDH1A1GAAMEN1KMT2A
SCHEMBL811303 0.81 CES2 (0.44) POLBCES2CES1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109852242-A A kind of hydrophobic oil resistant flame-retardant anti-corrosion multifunctional coating and preparation method 北京化工大学 2019-06-07 CN disclosed