Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LPO | P22079 | 2/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753105 | 0.73 | TSHR (0.33) | TSHRLPOP2RX4 | |
| SCHEMBL5928592 | 0.72 | — | — | |
| SCHEMBL5344293 | 0.71 | MAPK1 (0.38) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL5535740 | 0.69 | — | — | |
| SCHEMBL5088038 | 0.67 | — | — | |
| SCHEMBL2009602 | 0.67 | — | — | |
| SCHEMBL1649446 | 0.67 | TSHR (0.33) | TSHR | |
| SCHEMBL7641213 | 0.65 | TSHR (0.31) | TSHRLPO | |
| SCHEMBL30491883 | 0.64 | — | — | |
| SCHEMBL6602093 | 0.64 | P2RX4 (0.32) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109863140-A | 3- oxo -2,6- diphenyl -2,3- dihydrogen dazin -4- formamide | 拜耳医药股份有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-102304086-B | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC | 2013-12-04 | — | — | CN | disclosed |
| CN-102942522-A | Heterocyclic inhibitors of mek and methods of use thereof | ARRAY BIOPHARMA INC | 2013-02-27 | — | — | CN | disclosed |
| CN-102898364-A | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC | 2013-01-30 | — | — | CN | disclosed |
| CN-102633716-A | Bicyclic inhibitors of mek and methods of use thereof | ARRAY BIOPHARMA INC | 2012-08-15 | — | — | CN | disclosed |
| CN-102321030-A | The heterocycle inhibitor of MEK and method of use thereof | ARRAY BIOPHARMA INC | 2012-01-18 | — | — | CN | disclosed |
| CN-102304086-A | Heterocyclic inhibitors of MEK and methods of use thereof | ASTRAZENECA AB | 2012-01-04 | — | — | CN | disclosed |
| CN-101626767-A | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC | 2010-01-13 | — | — | CN | disclosed |
| CN-1905873-A | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC (US) | 2007-01-31 | — | — | CN | disclosed |