SCHEMBL5344293

SCHEMBL5344293

COC(=O)N1C=CCC=C1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.38
TSHR P16473 1/20 0.37
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
CHRNB2 P17787 2/20 0.32
CHRNA4 P43681 2/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
LPO P22079 2/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
KDM4E B2RXH2 1/20 0.31
LMNA P02545 1/20 0.31
POLB P06746 1/20 0.31
GAA P10253 1/20 0.31
NFKB1 P19838 1/20 0.31
XDH P47989 1/20 0.31
GFER P55789 1/20 0.31
NFKB2 Q00653 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11317425 0.77 ALDH1A1 (0.39) TSHRALDH1A1MAPTSMN1; SMN2LPO
SCHEMBL9753105 0.73 TSHR (0.33) TSHRALDH1A1LPOP2RX4
SCHEMBL11492907 0.72
SCHEMBL28785551 0.71
SCHEMBL1043081 0.69
SCHEMBL10720382 0.69
SCHEMBL8832747 0.68 TSHR (0.32) TSHRALDH1A1MAPTKMT2ASMN1; SMN2
SCHEMBL10720317 0.67 SERPINE1 (0.31) SMN1; SMN2LMNAPOLB
SCHEMBL4009184 0.67 KDM4E (0.38) TSHRKMT2ASMN1; SMN2KDM4EGAA
SCHEMBL1649446 0.67 TSHR (0.33) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190169328-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF RENQIU LIHE TECH LTD (CN) 2019-06-06 US disclosed
US-20170355792-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF RENQIU LIHE TECH LTD (CN) 2017-12-14 US disclosed
US-7196150-B2 Method for radical polymerisation in the presence of a chain transfer agent BASF AKTIENGESELLSCHAFT (DE) 2007-03-27 US disclosed
US-20060058478-A1 Method for radical polymerisation in the presence of a chain transfer agent BASF AKTIENGESELLSCHAFT (DE) 2006-03-16 US disclosed
US-6392050-B2 REACTING 1,4-DIHYDROPYRIDINE WITH METHYL NITRITE IN PRESENCE OF ACID CATALYST BAYER AKTIENGESELLSCHAFT (DE) 2002-05-21 US disclosed
EP-0260675-A1 4-[N-(substituted)-aminophenyl]-substituted 1,4-di-(hydro)-pyridine derivatives, process for their preparation and medicaments containing them ALKALOIDA VEGYESZETI GYAR (HU) 1988-03-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190169328-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF COG2, GTF2I, POF1B MAPK1 1884/4885TSHR 2613/4885ALDH1A1 2055/4885
US-20170355792-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF COG2, COG7, COG4 MAPK1 3793/4885TSHR 3704/4885ALDH1A1 2496/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.